Deep within a subterranean biosphere, astrobiologists cultivate a bioluminescent eukaryote whose cellular division can be tracked via real-time fluorescent microscopy. When a newly discovered fungal compound is applied to dividing cultures, chromosomes successfully condense and assemble along the equatorial metaphase plate. However, the sister chromatids remain locked together indefinitely and fail to migrate toward opposite spindle poles. Which molecular event was directly blocked by this compound?

A) Condensation of diffuse chromatin into distinct sister chromatid pairs

B) Disassembly of the nuclear envelope and dispersion of the nucleolus

C) Semiconservative replication of genomic DNA during interphase

D) Proteolytic cleavage of cohesin proteins holding sister chromatids together

Mitosis Original Scenario-Based Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Cycle & Cell Division

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Cell Communication & the Cell Cycle · Biology

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