Mitosis Transitional Reasoning Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Cycle & Cell Division

1 Biology practice questions on Mitosis. Questions that build towards applied reasoning.

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  1. 1.

    A research team treats actively dividing human cells with an experimental molecule that selectively prevents the degradation of securin, an inhibitory protein that keeps the enzyme separase inactive. The cells progress normally through the early stages of the cell cycle and enter mitosis, where spindle fibers successfully attach to kinetochores. Based on the mechanism of chromosome movement during cell division, which of the following cellular outcomes is expected in these treated cells?

    • A) The cells bypass mitosis entirely and complete cytokinesis without dividing their replicated nuclear content.
    • B) Nuclear envelopes reform prematurely around condensed chromatin before spindle microtubules can interact with kinetochores.
    • C) Replicated chromosomes align at the equatorial plate, but sister chromatids fail to separate and move toward opposite poles.
    • D) Centrosomes fail to migrate to opposite cell poles, preventing the polymerization and assembly of mitotic spindle microtubules.

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