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Receptors and ligands Original Scenario-Based Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Communication

1 Biology practice questions on Receptors and ligands. Questions built around original scenarios.

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  1. 1.

    Biochemists studying the bioluminescent glimmer-cells of deep-sea siphonophores isolate an unknown signaling molecule named Glimmerin-B, identifying it as a large, water-soluble polypeptide. When researchers microinject Glimmerin-B directly into the cytosol of an unactivated cell, no light emission or downstream activity occurs. However, exposing intact cells to extracellular Glimmerin-B immediately triggers a rapid phosphorylation cascade followed by brilliant blue luminescence. Which conclusion regarding Glimmerin-B and its receptor is best supported by these observations?

    • A) Glimmerin-B diffuses freely through the phospholipid bilayer to activate a nuclear receptor.
    • B) Glimmerin-B acts as a lipid-soluble hormone that directly enters and binds a cytosolic receptor.
    • C) Glimmerin-B requires transport into the mitochondrial matrix to initiate ATP-dependent light production.
    • D) Glimmerin-B functions as an extracellular ligand that binds specifically to a cell-surface plasma membrane receptor.

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