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Cell cycle regulation (cyclins, checkpoints) Original Scenario-Based Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Cycle & Cell Division

1 Biology practice questions on Cell cycle regulation (cyclins, checkpoints). Questions built around original scenarios.

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  1. 1.

    In an imaginative deep-sea research station, scientists discover that regenerative dermal cells of an abyssal siphonophore abruptly arrest their cell cycle under extreme hydrostatic pressure. Molecular assays reveal that while DNA replication in S phase and centrosome duplication are fully accomplished, pressure-sensitive proteases continuously degrade Cyclin B immediately upon translation. Based on cell cycle regulation mechanisms, what is the direct biochemical reason these cells fail to cross the G2/M boundary into mitosis?

    • A) The cells cannot phosphorylate the retinoblastoma protein (Rb) to release E2F transcription factors.
    • B) The cells cannot form functional Maturation Promoting Factor (MPF) complexes to initiate prophase events.
    • C) The spindle assembly checkpoint remains triggered due to unattached kinetochores.
    • D) Anaphase-promoting complex/cyclosome (APC/C) fails to target securin for ubiquitination.

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