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Cell cycle regulation (cyclins, checkpoints) Knowledge-Based Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Cycle & Cell Division

1 Biology practice questions on Cell cycle regulation (cyclins, checkpoints). Questions that assess core concepts and understanding.

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  1. 1.

    Which of the following best describes the molecular mechanism by which cyclins regulate cyclin-dependent kinase (CDK) activity during cell cycle checkpoints?

    • A) CDK protein concentrations fluctuate cyclically, directly phosphorylating checkpoint proteins without requiring regulatory subunits.
    • B) Cyclin concentrations fluctuate throughout the cycle, binding to and activating constitutively present CDKs to phosphorylate target proteins.
    • C) Cyclins function as active protein kinases that bypass CDKs to trigger chromosome segregation during the M checkpoint.
    • D) CDKs are rapidly degraded at each checkpoint to release trapped cyclins, allowing free cyclins to transcribe replication enzymes.

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