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Changes in signal transduction and disease Knowledge-Based Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Communication

1 Biology practice questions on Changes in signal transduction and disease. Questions that assess core concepts and understanding.

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  1. 1.

    Vibrio cholerae produces a toxin that chemically modifies a G protein involved in regulating salt and water secretion in intestinal epithelial cells. What is the direct molecular consequence of this modification that leads to disease pathology?

    • A) The G protein is prevented from exchanging GDP for GTP, thereby preventing adenylyl cyclase activation.
    • B) The G protein is locked in its active GTP-bound state, continuously stimulating adenylyl cyclase to produce cyclic AMP.
    • C) The G protein is targeted for immediate lysosomal degradation, terminating intracellular phosphorylation cascades.
    • D) The G protein binds irreversibly to extracellular surface receptors, directly blocking the uptake of sodium ions.

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