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Positive and negative feedback Knowledge-Based Practice

Biology · Cell Communication & the Cell Cycle · Biology · Cell Communication

1 Biology practice questions on Positive and negative feedback. Questions that assess core concepts and understanding.

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  1. 1.

    Which of the following scenarios best illustrates a negative feedback mechanism in a cell communication pathway?

    • A) Binding of a growth factor induces continuous receptor phosphorylation, causing perpetual activation of downstream transcription factors without attenuation.
    • B) An activated downstream protein kinase phosphorylates and inactivates the upstream cell-surface receptor, diminishing further pathway signaling.
    • C) Inositol trisphosphate stimulates calcium release from the endoplasmic reticulum, which binds to neighboring channels to trigger further calcium efflux.
    • D) Active cyclin B–CDK1 complexes phosphorylate and activate Cdc25 phosphatase, accelerating the formation of additional active cyclin B–CDK1 complexes.

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