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Free energy Transitional Reasoning Practice

Biology · Cellular Energetics · Biology · Energy & Metabolism

1 Biology practice questions on Free energy. Questions that build towards applied reasoning.

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  1. 1.

    An intracellular anabolic reaction converting metabolite X into metabolite Y is endergonic, possessing a positive standard free-energy change of +14.2 kJ/mol. To drive this non-spontaneous transformation, the cell couples the conversion to the hydrolysis of ATP, which has a standard free-energy change of -30.5 kJ/mol. Based on the thermodynamic principles of cellular energetics, which statement correctly explains how this coupling allows the synthesis of metabolite Y to occur?

    • A) The hydrolysis of ATP lowers the activation energy of the conversion, making the individual synthesis of metabolite Y spontaneously favorable.
    • B) The coupling process alters the intrinsic equilibrium constant of ATP hydrolysis alone, eliminating the requirement for free energy consumption.
    • C) The combined reaction establishes an overall positive free-energy change that releases excess heat to satisfy the entropic penalty.
    • D) The combined reaction results in a negative net free-energy change, rendering the overall coupled pathway exergonic and thermodynamically favorable.

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