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Krebs cycle Transitional Reasoning Practice

Biology · Cellular Energetics · Biology · Cellular Respiration

1 Biology practice questions on Krebs cycle. Questions that build towards applied reasoning.

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  1. 1.

    In an experiment investigating cellular energetics, researchers supply isolated mitochondria with acetyl-CoA and monitor pathway intermediates. The addition of a targeted metabolic inhibitor halts the activity of malate dehydrogenase, causing malate to accumulate rapidly. Which outcome describes the most direct consequence of this specific inhibition on the metabolic yield produced per entering acetyl group during that cycle turn?

    • A) The generation of the third NADH molecule is prevented, whereas two molecules of carbon dioxide are still released.
    • B) The synthesis of FADH2 is prevented, whereas three molecules of NADH are successfully produced.
    • C) The release of carbon dioxide is completely abolished, whereas substrate-level phosphorylation proceeds normally.
    • D) The production of ATP via substrate-level phosphorylation is blocked, whereas all electron carriers are fully reduced.

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