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DNA replication Knowledge-Based Practice

Biology · Molecular Genetics · Biology · DNA Structure & Replication

1 Biology practice questions on DNA replication. Questions that assess core concepts and understanding.

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Questions

  1. 1.

    During DNA replication, why is the lagging strand synthesized discontinuously as Okazaki fragments rather than continuously?

    • A) DNA polymerase can only add nucleotides in the 5' to 3' direction, while the template strand unwinds in the opposite relative orientation.
    • B) RNA primase cannot bind to the lagging strand template until the replication fork has completely opened.
    • C) Topoisomerase prevents DNA helicase from unwinding both template strands at identical rates.
    • D) DNA ligase degrades continuous DNA segments on the lagging strand to maintain structural balance.

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