Mitosis Transitional Reasoning Download PDF

Questions

1. 1.

   A researcher studying mitotic division in cultured mammalian cells introduces a specific inhibitor that blocks the proteolytic activity of separase, an enzyme essential for cleaving cohesin proteins. The cells are provided with all necessary growth factors and examined under a fluorescence microscope to evaluate mitotic progression. Which outcome will be observed in these treated cells compared to untreated control cells?

   • A) Cells fail to assemble the mitotic spindle and remain arrested in prophase before the nuclear envelope disintegrates.
   • B) Chromatin fails to undergo condensation, preventing individual duplicated chromosomes from aligning at the equatorial plane.
   • C) Kinetochores detach prematurely from spindle microtubules during prometaphase, causing multipolar spindle formation.
   • D) Chromosomes align normally at the metaphase plate, but sister chromatids fail to separate and migrate toward opposite poles.