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Changes in signal transduction and disease

Biology • Cell Communication • Knowledge-Based • 1 questions

Changes in signal transduction and disease Knowledge-Based Download PDF

Biology · Cell Communication & the Cell Cycle · Biology · Cell Communication

1 Biology practice questions on Changes in signal transduction and disease. Questions that assess core concepts and understanding.

Questions

  1. 1.

    A point mutation in the gene encoding the Ras protein impairs its intrinsic GTPase activity, preventing the hydrolysis of bound GTP to GDP. Which of the following is the most direct consequence of this alteration in the signal transduction pathway?

    • A) The pathway is permanently inactivated because GTP cannot be exchanged for GDP.
    • B) Downstream protein kinases remain continuously active, leading to uncontrolled cell proliferation.
    • C) Receptor tyrosine kinases at the cell surface are irreversibly blocked from binding extracellular ligands.
    • D) Adenylyl cyclase is continuously inhibited, causing a rapid decline in intracellular cAMP levels.