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Chromosomes and chromatin Original Scenario-Based Practice

Biology · Molecular Genetics · Biology · DNA Structure & Replication

1 Biology practice questions on Chromosomes and chromatin. Questions built around original scenarios.

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  1. 1.

    In the bioluminescent micro-city of Nucleopolis, molecular courier Vesper oversees the cellular library where vital genetic blueprints must be safely relocated during cellular division. To prevent long, fragile DNA threads from tangling and snapping when the cell splits, Vesper's crew must convert the loose, transcriptionally accessible chromatin into dense, transport-ready chromosome units. Which of the following best describes the structural transformation and functional state of the genetic material as chromatin condenses into metaphase chromosomes?

    • A) The DNA strands shed their histone octamers completely, forming rigid naked double-helices that can be directly pulled to opposite poles.
    • B) The chromatin unwinds entirely into linear single-stranded DNA to decrease its overall molecular diameter for rapid transit.
    • C) Nucleosomes coil and loop into progressively tighter fibers around scaffold proteins, dramatically shortening the DNA length while temporarily shutting down most gene transcription.
    • D) Heterochromatin expands into diffuse, highly uncoiled loops so that RNA polymerases can accelerate transcription during sister chromatid separation.

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