A research team investigating cellular energetics adds a selective chemical inhibitor of the pyruvate dehydrogenase complex to a suspension of isolated, metabolically active mitochondria supplied with pyruvate and necessary cofactors. Which of the following profiles accurately describes the immediate biochemical consequences observed within the mitochondrial matrix following this inhibition?

A) An increase in matrix acetyl-CoA levels accompanied by accelerated reduction of NAD+.

B) A rapid accumulation of citrate and an elevated rate of carbon dioxide gas release.

C) A sustained elevation in ATP synthesis driven by independent substrate-level phosphorylation.

D) An accumulation of pyruvate accompanied by a decrease in both acetyl-CoA synthesis and NADH generation.

Pyruvate oxidation Transitional Reasoning Download PDF

Biology · Cellular Energetics · Biology · Cellular Respiration

1 Biology practice questions on Pyruvate oxidation. Questions that build towards applied reasoning.

Cellular Energetics · Biology

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